Apoptosis in development

Pascal Meier (), Andrew Finch () and Gerard Evan ()
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Pascal Meier: Signal Transduction Laboratory, Imperial Cancer Research Fund
Andrew Finch: UCSF Cancer Center
Gerard Evan: UCSF Cancer Center

Nature, 2000, vol. 407, issue 6805, 796-801

Abstract: Abstract Essential to the construction, maintenance and repair of tissues is the ability to induce suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study of three principal organisms — the nematode, fruitfly and mouse — indicate that cell suicide is implemented through the activation of an evolutionarily conserved molecular programme intrinsic to all metazoan cells. Dysfunctions in the regulation or execution of cell suicide are implicated in a wide range of developmental abnormalities and diseases.

Date: 2000
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DOI: 10.1038/35037734

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