Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

Julia Parrish-Novak, Stacey R. Dillon, Andrew Nelson, Angie Hammond, Cindy Sprecher, Jane A. Gross, Janet Johnston, Karen Madden, Wenfeng Xu, Jim West, Sara Schrader, Steve Burkhead, Mark Heipel, Cameron Brandt, Joseph L. Kuijper, Janet Kramer, Darrell Conklin, Scott R. Presnell, Jon Berry, Faith Shiota, Susan Bort, Kevin Hambly, Sherri Mudri, Chris Clegg, Margaret Moore, Francis J. Grant, Catherine Lofton-Day, Teresa Gilbert, Fenella Raymond, Andrew Ching, Lena Yao, Deb Smith, Philippa Webster, Theodore Whitmore, Mark Maurer, Kenneth Kaushansky, Rick D. Holly and Don Foster ()
Additional contact information
Julia Parrish-Novak: Departments of Functional Cloning
Stacey R. Dillon: Departments of Immunology
Andrew Nelson: Departments of Immunology
Angie Hammond: Departments of Functional Cloning
Cindy Sprecher: Departments of Functional Cloning
Jane A. Gross: Departments of Immunology
Janet Johnston: Departments of Immunology
Karen Madden: Departments of Functional Cloning
Wenfeng Xu: Departments of Functional Cloning
Jim West: Departments of Protein Biochemistry
Sara Schrader: Departments of Functional Cloning
Steve Burkhead: Departments of Functional Cloning
Mark Heipel: Departments of Functional Cloning
Cameron Brandt: Departments of Functional Cloning
Joseph L. Kuijper: Departments of Functional Cloning
Janet Kramer: Departments of Functional Cloning
Darrell Conklin: Departments of Biomolecular Informatics
Scott R. Presnell: Departments of Biomolecular Informatics
Jon Berry: Departments of Protein Biochemistry
Faith Shiota: Departments of Immunology
Susan Bort: Departments of Immunology
Kevin Hambly: Departments of Immunology
Sherri Mudri: Departments of Immunology
Chris Clegg: Departments of Immunology
Margaret Moore: Genetics, ZymoGenetics, Inc.
Francis J. Grant: Departments of Biomolecular Informatics
Catherine Lofton-Day: Genetics, ZymoGenetics, Inc.
Teresa Gilbert: Genetics, ZymoGenetics, Inc.
Fenella Raymond: Genetics, ZymoGenetics, Inc.
Andrew Ching: Departments of Biomolecular Informatics
Lena Yao: Genetics, ZymoGenetics, Inc.
Deb Smith: Genetics, ZymoGenetics, Inc.
Philippa Webster: Genetics, ZymoGenetics, Inc.
Theodore Whitmore: Genetics, ZymoGenetics, Inc.
Mark Maurer: Genetics, ZymoGenetics, Inc.
Kenneth Kaushansky: University of Washington, School of Medicine
Rick D. Holly: Departments of Functional Cloning
Don Foster: Departments of Functional Cloning

Nature, 2000, vol. 408, issue 6808, 57-63

Abstract: Abstract Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal transduction. The full-length receptor was expressed in BaF3 cells, which created a functional assay for ligand detection and cloning. Conditioned media from activated human CD3+ T cells supported proliferation of the assay cell line. We constructed a complementary DNA expression library from activated human CD3+ T cells, and identified a cytokine with a four-helix-bundle structure using functional cloning. This cytokine is most closely related to IL2 and IL15, and has been designated IL21 with the receptor designated IL21R. In vitro assays suggest that IL21 has a role in the proliferation and maturation of natural killer (NK) cell populations from bone marrow, in the proliferation of mature B-cell populations co-stimulated with anti-CD40, and in the proliferation of T cells co-stimulated with anti-CD3.

Date: 2000
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DOI: 10.1038/35040504

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