Oxidants, oxidative stress and the biology of ageing

Toren Finkel () and Nikki J. Holbrook ()
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Toren Finkel: Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Building 10/6N-240
Nikki J. Holbrook: Laboratory of Biological Chemistry, National Institute on Aging/National Institutes of Health

Nature, 2000, vol. 408, issue 6809, 239-247

Abstract: Abstract Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

Date: 2000
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DOI: 10.1038/35041687

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