The DNA damage response: putting checkpoints in perspective

Bin-Bing S. Zhou and Stephen J. Elledge ()
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Bin-Bing S. Zhou: Department of Oncology Research SmithKline Beecham Pharmaceuticals
Stephen J. Elledge: Howard Hughes Medical Institute, Baylor College of Medicine

Nature, 2000, vol. 408, issue 6811, 433-439

Abstract: Abstract The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.

Date: 2000
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DOI: 10.1038/35044005

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