DNA methylation in Drosophila melanogaster

Frank Lyko, Bernard H. Ramsahoye and Rudolf Jaenisch ()
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Frank Lyko: Whitehead Institute for Biomedical Research
Bernard H. Ramsahoye: John Hughes Bennett Laboratory, University of Edinburgh, Western General Hospital
Rudolf Jaenisch: Whitehead Institute for Biomedical Research

Nature, 2000, vol. 408, issue 6812, 538-540

Abstract: Abstract Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception1,2,3,4, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well5,6,7,9. Here we show that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.

Date: 2000
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DOI: 10.1038/35046205

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