Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Dave Morgan (), David M. Diamond, Paul E. Gottschall, Kenneth E. Ugen, Chad Dickey, John Hardy, Karen Duff, Paul Jantzen, Giovanni DiCarlo, Donna Wilcock, Karen Connor, Jaime Hatcher, Caroline Hope, Marcia Gordon and Gary W. Arendash
Additional contact information
Dave Morgan: Alzheimer Research Laboratory
David M. Diamond: Department of Psychology
Paul E. Gottschall: Alzheimer Research Laboratory
Kenneth E. Ugen: Department of Medical Microbiology and Immunology
Chad Dickey: Department of Medical Microbiology and Immunology
John Hardy: Mayo Clinic
Karen Duff: Nathan Kline Institute
Paul Jantzen: Alzheimer Research Laboratory
Giovanni DiCarlo: Alzheimer Research Laboratory
Donna Wilcock: Alzheimer Research Laboratory
Karen Connor: Alzheimer Research Laboratory
Jaime Hatcher: University of South Florida
Caroline Hope: University of South Florida
Marcia Gordon: Alzheimer Research Laboratory
Gary W. Arendash: University of South Florida

Nature, 2000, vol. 408, issue 6815, 982-985

Abstract: Abstract Vaccinations with amyloid-β peptide (AB) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease1. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight months of Aβ vaccination in a different transgenic model for Alzheimer's disease in which mice develop learning deficits as amyloid accumulates2,3 . Here we show that vaccination with Aβ protects transgenic mice from the learning and age-related memory deficits that normally occur in this mouse model for Alzheimer's disease. During testing for potential deleterious effects of the vaccine, all mice performed superbly on the radial-arm water-maze test of working memory. Later, at an age when untreated transgenic mice show memory deficits, the Aβ-vaccinated transgenic mice showed cognitive performance superior to that of the control transgenic mice and, ultimately, performed as well as nontransgenic mice. The Aβ-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia.

Date: 2000
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DOI: 10.1038/35050116

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