Controlled growth factor release from synthetic extracellular matrices

Kuen Yong Lee, Martin C. Peters, Kenneth W. Anderson and David J. Mooney ()
Additional contact information
Kuen Yong Lee: Departments of Biologic & Materials Sciences
Martin C. Peters: Biomedical Engineering
Kenneth W. Anderson: Departments of Biologic & Materials Sciences
David J. Mooney: Departments of Biologic & Materials Sciences

Nature, 2000, vol. 408, issue 6815, 998-1000

Abstract: Abstract Polymeric matrices can be used to grow new tissues and organs1,2, and the delivery of growth factors from these matrices is one method to regenerate tissues3,4. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels5,6, is that most drug delivery systems have been designed to operate under static conditions. We thought that polymeric matrices, which release growth factors in response to mechanical signals, might provide a new approach to guide tissue formation in mechanically stressed environments. Critical design features for this type of system include the ability to undergo repeated deformation, and a reversible binding of the protein growth factors to polymeric matrices to allow for responses to repeated stimuli. Here we report a model delivery system that can respond to mechanical signalling and upregulate the release of a growth factor to promote blood vessel formation. This approach may find a number of applications, including regeneration and engineering of new tissues and more general drug-delivery applications.

Date: 2000
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/35050141 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:408:y:2000:i:6815:d:10.1038_35050141

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35050141

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().