Identification of the haemoglobin scavenger receptor

Mette Kristiansen, Jonas H. Graversen, Christian Jacobsen, Ole Sonne, Hans-Jürgen Hoffman, S.K. Alex Law and Søren K. Moestrup ()
Additional contact information
Mette Kristiansen: Department of Medical Biochemistry
Jonas H. Graversen: Department of Medical Biochemistry
Christian Jacobsen: Department of Medical Biochemistry
Ole Sonne: University of Aarhus
Hans-Jürgen Hoffman: Department of Respiratory Diseases Aarhus University Hospital
S.K. Alex Law: MRC Immunochemistry Unit, University of Oxford
Søren K. Moestrup: Department of Medical Biochemistry

Nature, 2001, vol. 409, issue 6817, 198-201

Abstract: Abstract Intravascular haemolysis is a physiological phenomenon as well as a severe pathological complication when accelerated in various autoimmune, infectious (such as malaria) and inherited (such as sickle cell disease) disorders1. Haemoglobin released into plasma is captured by the acute phase protein haptoglobin, which is depleted from plasma during elevated haemolysis1. Here we report the identification of the acute phase-regulated and signal-inducing macrophage protein, CD163, as a receptor that scavenges haemoglobin by mediating endocytosis of haptoglobin–haemoglobin complexes. CD163 binds only haptoglobin and haemoglobin in complex, which indicates the exposure of a receptor-binding neoepitope. The receptor–ligand interaction is Ca2+-dependent and of high affinity. Complexes of haemoglobin and multimeric haptoglobin (the 2-2 phenotype) exhibit higher functional affinity for CD163 than do complexes of haemoglobin and dimeric haptoglobin (the 1-1 phenotype). Specific CD163-mediated endocytosis of haptoglobin–haemoglobin complexes is measurable in cells transfected with CD163 complementary DNA and in CD163-expressing myelo-monocytic lymphoma cells.

Date: 2001
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/35051594 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:409:y:2001:i:6817:d:10.1038_35051594

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35051594

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().