Enabling the chemistry of life

Christopher Walsh
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Christopher Walsh: Biological Chemistry and Molecular Pharmacology Department Harvard Medical School

Nature, 2001, vol. 409, issue 6817, 226-231

Abstract: Abstract Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions.

Date: 2001
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DOI: 10.1038/35051697

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