Genome sequence of enterohaemorrhagic Escherichia coli O157:H7

Nicole T. Perna (), Guy Plunkett, Valerie Burland, Bob Mau, Jeremy D. Glasner, Debra J. Rose, George F. Mayhew, Peter S. Evans, Jason Gregor, Heather A. Kirkpatrick, György Pósfai, Jeremiah Hackett, Sara Klink, Adam Boutin, Ying Shao, Leslie Miller, Erik J. Grotbeck, N. Wayne Davis, Alex Lim, Eileen T. Dimalanta, Konstantinos D. Potamousis, Jennifer Apodaca, Thomas S. Anantharaman, Jieyi Lin, Galex Yen, David C. Schwartz, Rodney A. Welch and Frederick R. Blattner
Additional contact information
Nicole T. Perna: Genome Center of Wisconsin,
Guy Plunkett: Laboratory of Genetics
Valerie Burland: Laboratory of Genetics
Bob Mau: Laboratory of Genetics
Jeremy D. Glasner: Laboratory of Genetics
Debra J. Rose: Laboratory of Genetics
George F. Mayhew: Laboratory of Genetics
Peter S. Evans: Laboratory of Genetics
Jason Gregor: Laboratory of Genetics
Heather A. Kirkpatrick: Laboratory of Genetics
György Pósfai: Institute of Biochemistry, Biological Research Center
Jeremiah Hackett: Laboratory of Genetics
Sara Klink: Laboratory of Genetics
Adam Boutin: Laboratory of Genetics
Ying Shao: Laboratory of Genetics
Leslie Miller: Laboratory of Genetics
Erik J. Grotbeck: Laboratory of Genetics
N. Wayne Davis: Laboratory of Genetics
Alex Lim: Department of Chemistry
Eileen T. Dimalanta: Department of Chemistry
Konstantinos D. Potamousis: Laboratory of Genetics
Jennifer Apodaca: Laboratory of Genetics
Thomas S. Anantharaman: Department of Biostatistics
Jieyi Lin: Cereon Genomics, LLC
Galex Yen: Genome Center of Wisconsin,
David C. Schwartz: Genome Center of Wisconsin,
Rodney A. Welch: University of Wisconsin
Frederick R. Blattner: Genome Center of Wisconsin,

Nature, 2001, vol. 409, issue 6819, 529-533

Abstract: Abstract The bacterium Escherichia coli O157:H7 is a worldwide threat to public health and has been implicated in many outbreaks of haemorrhagic colitis, some of which included fatalities caused by haemolytic uraemic syndrome1,2. Close to 75,000 cases of O157:H7 infection are now estimated to occur annually in the United States3. The severity of disease, the lack of effective treatment and the potential for large-scale outbreaks from contaminated food supplies have propelled intensive research on the pathogenesis and detection of E. coli O157:H7 (ref. 4). Here we have sequenced the genome of E. coli O157:H7 to identify candidate genes responsible for pathogenesis, to develop better methods of strain detection and to advance our understanding of the evolution of E. coli, through comparison with the genome of the non-pathogenic laboratory strain E. coli K-12 (ref. 5). We find that lateral gene transfer is far more extensive than previously anticipated. In fact, 1,387 new genes encoded in strain-specific clusters of diverse sizes were found in O157:H7. These include candidate virulence factors, alternative metabolic capacities, several prophages and other new functions—all of which could be targets for surveillance.

Date: 2001
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DOI: 10.1038/35054089

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