Scabrous complexes with Notch to mediate boundary formation

Patricia A. Powell, Cedric Wesley, Susan Spencer and Ross L. Cagan ()
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Patricia A. Powell: Washington University School of Medicine
Cedric Wesley: Laboratory of Genetics, The Rockefeller University
Susan Spencer: Washington University School of Medicine
Ross L. Cagan: Washington University School of Medicine

Nature, 2001, vol. 409, issue 6820, 626-630

Abstract: Abstract The mechanisms that establish and sharpen pattern across epithelia are poorly understood. In the developing nervous system, the first pattern elements appear as ‘proneural clusters’. In the morphogenetic furrow of the immature Drosophila retina proneural clusters emerge in a wave as a patterned array of 6–10-cell groups, which are recognizable by expression of Atonal, a basic helix–loop–helix transcription factor that is required to establish and pattern the first cell fate1,2,3. The establishment and subsequent patterning of Atonal expression requires activity of the signalling transmembrane receptor Notch2,4. Here we present in vivo and biochemical evidence that the secreted protein Scabrous associates with Notch, and can stabilize Notch protein at the surface. The result is a regulation of Notch activity that sharpens proneural cluster boundaries and ensures establishment of single pioneer neurons.

Date: 2001
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DOI: 10.1038/35054566

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