Expressing the human genome

Rossella Tupler, Giovanni Perini and Michael R. Green ()
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Rossella Tupler: Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School
Giovanni Perini: University of Bologna
Michael R. Green: Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School

Nature, 2001, vol. 409, issue 6822, 832-833

Abstract: Abstract We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared with Drosophila melanogaster and Caenorhabditis elegans. Although the raw genomic information has limitations, its availability offers new experimental approaches for studying gene expression.

Date: 2001
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DOI: 10.1038/35057011

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