A genomic view of immunology

Aude M. Fahrer (), J. Fernando Bazan, Peter Papathanasiou, Keats A. Nelms and Christopher C. Goodnow
Additional contact information
Aude M. Fahrer: ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University
J. Fernando Bazan: DNAX Research Institute
Peter Papathanasiou: ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University
Keats A. Nelms: ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University
Christopher C. Goodnow: ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University

Nature, 2001, vol. 409, issue 6822, 836-838

Abstract: Abstract The outstanding problems facing immunology are whole system issues: curing allergic and autoimmune disease and developing vaccines to stimulate stronger immune responses against pathogenic organisms and cancer. We hope that the human genome sequence will reveal the molecular checks and balances that ensure both an effective immunogenic response against pathogenic microorganisms and a suitably tolerogenic response to self antigens and innocuous environmental antigens. Three synergistic approaches—sequence homology searches, messenger RNA expression profiling on microarrays, and mutagenesis in mice—provide the best opportunities to reveal, in the genome sequence, key proteins and pathways for targeting by new immunomodulatory treatments.

Date: 2001
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35057020 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:409:y:2001:i:6822:d:10.1038_35057020

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35057020

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().