A genomic perspective on membrane compartment organization

Jason B. Bock, Hugo T. Matern, Andrew A. Peden and Richard H. Scheller ()
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Jason B. Bock: Howard Hughes Medical Institute, Stanford University School of Medicine
Hugo T. Matern: Howard Hughes Medical Institute, Stanford University School of Medicine
Andrew A. Peden: Howard Hughes Medical Institute, Stanford University School of Medicine
Richard H. Scheller: Howard Hughes Medical Institute, Stanford University School of Medicine

Nature, 2001, vol. 409, issue 6822, 839-841

Abstract: Abstract Now that whole genome sequences are available for many eukaryotic organisms from yeast to man, we can form broad hypotheses on the basis of the relative expansion of protein families. To investigate the molecular mechanisms responsible for the organization of membrane compartments, we identified members of the SNARE, coat complex, Rab and Sec1 protein families in four eukaryotic genomes. Of these families only the Rab family expanded from the unicellular yeast to the multicellular fly and worm. All families were expanded in humans, where we find 35 SNAREs, 60 Rabs and 53 coat complex subunits. In addition, we were able to resolve the SNARE class of proteins into four distinct subfamilies.

Date: 2001
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DOI: 10.1038/35057024

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