Cancer and genomics

P. Andrew Futreal, Arek Kasprzyk, Ewan Birney, James C. Mullikin, Richard Wooster and Michael R. Stratton ()
Additional contact information
P. Andrew Futreal: Cancer Genome Project and
Arek Kasprzyk: EBI-EMBL, Wellcome Trust Genome Campus
Ewan Birney: EBI-EMBL, Wellcome Trust Genome Campus
James C. Mullikin: Informatics Division, Sanger Centre, Wellcome Trust Genome Campus
Richard Wooster: Cancer Genome Project and
Michael R. Stratton: Cancer Genome Project and

Nature, 2001, vol. 409, issue 6822, 850-852

Abstract: Abstract Identification of the genes that cause oncogenesis is a central aim of cancer research. We searched the proteins predicted from the draft human genome sequence for paralogues of known tumour suppressor genes, but no novel genes were identified. We then assessed whether it was possible to search directly for oncogenic sequence changes in cancer cells by comparing cancer genome sequences against the draft genome. Apparently chimaeric transcripts (from oncogenic fusion genes generated by chromosomal translocations, the ends of which mapped to different genomic locations) were detected to the same degree in both normal and neoplastic tissues, indicating a significant level of false positives. Our experiment underscores the limited amount and variable quality of DNA sequence from cancer cells that is currently available.

Date: 2001
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DOI: 10.1038/35057046

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