Computational comparison of two draft sequences of the human genome

John Aach, Martha L. Bulyk, George M. Church (), Jason Comander, Adnan Derti and Jay Shendure
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John Aach: The Lipper Center for Computational Genetics
Martha L. Bulyk: Program in Biophysics
George M. Church: The Lipper Center for Computational Genetics
Jason Comander: Pathology, Harvard Medical School
Adnan Derti: The Lipper Center for Computational Genetics
Jay Shendure: The Lipper Center for Computational Genetics

Nature, 2001, vol. 409, issue 6822, 856-859

Abstract: Abstract We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. We look at a number of features of the sequences, including sequence gaps, continuity, consistency between the two sequences and patterns of DNA-binding protein motifs.

Date: 2001
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DOI: 10.1038/35057055

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