Mammalian MAP kinase signalling cascades

Lufen Chang and Michael Karin ()
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Lufen Chang: University of California San Diego
Michael Karin: University of California San Diego

Nature, 2001, vol. 410, issue 6824, 37-40

Abstract: Abstract Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.

Date: 2001
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DOI: 10.1038/35065000

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