Bone marrow cells regenerate infarcted myocardium

Donald Orlic, Jan Kajstura, Stefano Chimenti, Igor Jakoniuk, Stacie M. Anderson, Baosheng Li, James Pickel, Ronald McKay, Bernardo Nadal-Ginard, David M. Bodine, Annarosa Leri and Piero Anversa ()
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Donald Orlic: Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI
Jan Kajstura: New York Medical College
Stefano Chimenti: New York Medical College
Igor Jakoniuk: New York Medical College
Stacie M. Anderson: Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI
Baosheng Li: New York Medical College
James Pickel: Laboratory of Molecular Biology, NINDS, NIH
Ronald McKay: Laboratory of Molecular Biology, NINDS, NIH
Bernardo Nadal-Ginard: New York Medical College
David M. Bodine: Hematopoiesis Section, Genetics and Molecular Biology Branch, NHGRI
Annarosa Leri: New York Medical College
Piero Anversa: New York Medical College

Nature, 2001, vol. 410, issue 6829, 701-705

Abstract: Abstract Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time1. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation2,3,4,5; these events promote structural and functional repair6,7,8. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin-) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein9 by fluorescence-activated cell sorting on the basis of c-kit expression10. Shortly after coronary ligation, Lin- c-kit POS cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9?days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.

Date: 2001
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DOI: 10.1038/35070587

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