Cellular immune responses to HIV

Andrew J. McMichael and Sarah L. Rowland-Jones
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Andrew J. McMichael: MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital
Sarah L. Rowland-Jones: MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital

Nature, 2001, vol. 410, issue 6831, 980-987

Abstract: Abstract The cellular immune response to the human immunodeficiency virus, mediated by T lymphocytes, seems strong but fails to control the infection completely. In most virus infections, T cells either eliminate the virus or suppress it indefinitely as a harmless, persisting infection. But the human immunodeficiency virus undermines this control by infecting key immune cells, thereby impairing the response of both the infected CD4+ T cells and the uninfected CD8+ T cells. The failure of the latter to function efficiently facilitates the escape of virus from immune control and the collapse of the whole immune system.

Date: 2001
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DOI: 10.1038/35073658

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