Analysis of oral polio vaccine CHAT stocks

N. Berry (), C. Davis, A. Jenkins, D. Wood, P. Minor, G. Schild, M. Bottiger, H. Holmes and N. Almond
Additional contact information
N. Berry: Division of Retrovirology
C. Davis: Division of Retrovirology
A. Jenkins: Division of Retrovirology
D. Wood: Division of Virology
P. Minor: Division of Virology
G. Schild: National Institute for Biological Standards and Control
M. Bottiger: Karolinska Institute
H. Holmes: Division of Retrovirology
N. Almond: Division of Retrovirology

Nature, 2001, vol. 410, issue 6832, 1046-1047

Abstract: Abstract Batches of experimental oral vaccines against poliovirus (OPV CHAT) that were administered in Central Africa in the 1950s have been implicated in the origin of the AIDS pandemic because of possible retroviral contamination during the vaccine's manufacture, which allegedly involved chimpanzee kidney cells1. Here we use a molecular analysis to show that two CHAT type-1 polio vaccine stocks were prepared from macaque and not chimpanzee cells, and contain neither human nor simian immunodeficiency virus sequences. Our results do not support the hypothesis that these materials were responsible for the transmission of the AIDS virus to humans.

Date: 2001
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35074176 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:410:y:2001:i:6832:d:10.1038_35074176

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35074176

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().