Progenitor cells from human brain after death

Theo D. Palmer, Philip H. Schwartz, Philippe Taupin, Brian Kaspar, Stuart A. Stein and Fred H. Gage ()
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Theo D. Palmer: The Salk Institute, Laboratory of Genetics
Philip H. Schwartz: Children's Hospital of Orange County, Brain and Tissue Bank for Developmental Disorders
Philippe Taupin: The Salk Institute, Laboratory of Genetics
Brian Kaspar: The Salk Institute, Laboratory of Genetics
Stuart A. Stein: Children's Hospital of Orange County, Brain and Tissue Bank for Developmental Disorders
Fred H. Gage: The Salk Institute, Laboratory of Genetics

Nature, 2001, vol. 411, issue 6833, 42-43

Abstract: Abstract Culturing neural progenitor cells from the adult rodent brain has become routine1,2 and is also possible from human fetal tissue3,4, but expansion of these cells from postnatal and adult human tissue, although preferred for ethical reasons, has encountered problems5,6,7,8. Here we describe the isolation and successful propagation of neural progenitor cells from human postmortem tissues and surgical specimens. Although the relative therapeutic merits of adult and fetal progenitor cells still need to be assessed, our results may extend the application of these progenitor cells in the treatment of neurodegenerative diseases.

Date: 2001
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DOI: 10.1038/35075141

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