A glia-derived acetylcholine-binding protein that modulates synaptic transmission

August B. Smit (), Naweed I. Syed, Dick Schaap, Jan van Minnen, Judith Klumperman, Karel S. Kits, Hans Lodder, Roel C. van der Schors, René van Elk, Bertram Sorgedrager, KatjuS̆a Brejc, Titia K. Sixma and Wijnand P. M. Geraerts
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August B. Smit: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
Naweed I. Syed: University of Calgary
Dick Schaap: Organon Teknika B.V., Bioscience Research Unit
Jan van Minnen: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
Judith Klumperman: University Medical Center, Institute of Biomembranes and Center for Biogenetics
Karel S. Kits: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
Hans Lodder: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
Roel C. van der Schors: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
René van Elk: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
Bertram Sorgedrager: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology
KatjuS̆a Brejc: Netherlands Cancer Institute
Titia K. Sixma: Netherlands Cancer Institute
Wijnand P. M. Geraerts: Research Institute Neurosciences Vrije Universiteit, Faculty of Biology

Nature, 2001, vol. 411, issue 6835, 261-268

Abstract: Abstract There is accumulating evidence that glial cells actively modulate neuronal synaptic transmission. We identified a glia-derived soluble acetylcholine-binding protein (AChBP), which is a naturally occurring analogue of the ligand-binding domains of the nicotinic acetylcholine receptors (nAChRs). Like the nAChRs, it assembles into a homopentamer with ligand-binding characteristics that are typical for a nicotinic receptor; unlike the nAChRs, however, it lacks the domains to form a transmembrane ion channel. Presynaptic release of acetylcholine induces the secretion of AChBP through the glial secretory pathway. We describe a molecular and cellular mechanism by which glial cells release AChBP in the synaptic cleft, and propose a model for how they actively regulate cholinergic transmission between neurons in the central nervous system.

Date: 2001
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DOI: 10.1038/35077000

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