Proliferation, cell cycle and apoptosis in cancer

Gerard I. Evan and Karen H. Vousden
Additional contact information
Gerard I. Evan: UCSF Cancer Center
Karen H. Vousden: NCI at Frederick

Nature, 2001, vol. 411, issue 6835, 342-348

Abstract: Abstract Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.

Date: 2001
References: Add references at CitEc
Citations: View citations in EconPapers (12)

Downloads: (external link)
https://www.nature.com/articles/35077213 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077213

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35077213

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().