Genome maintenance mechanisms for preventing cancer

Jan H. J. Hoeijmakers ()
Additional contact information
Jan H. J. Hoeijmakers: Centre for Biomedical Genetics, Erasmus University

Nature, 2001, vol. 411, issue 6835, 366-374

Abstract: Abstract The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.

Date: 2001
References: Add references at CitEc
Citations: View citations in EconPapers (15)

Downloads: (external link)
https://www.nature.com/articles/35077232 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:411:y:2001:i:6835:d:10.1038_35077232

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35077232

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().