The microenvironment of the tumour–host interface

Lance A. Liotta and Elise C. Kohn
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Lance A. Liotta: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute
Elise C. Kohn: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute

Nature, 2001, vol. 411, issue 6835, 375-379

Abstract: Abstract Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour–host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate migration, and promote proliferation and survival. A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.

Date: 2001
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DOI: 10.1038/35077241

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