B cells acquire antigen from target cells after synapse formation

Facundo D. Batista (), Dagmar Iber and Michael S. Neuberger ()
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Facundo D. Batista: Medical Research Laboratory of Molecular Biology
Dagmar Iber: Medical Research Laboratory of Molecular Biology
Michael S. Neuberger: Medical Research Laboratory of Molecular Biology

Nature, 2001, vol. 411, issue 6836, 489-494

Abstract: Abstract Soluble antigen binds to the B-cell antigen receptor and is internalized for subsequent processing and the presentation of antigen-derived peptides to T cells1. Many antigens are not soluble, however, but are integral components of membrane; furthermore, soluble antigens will usually be encountered in vivo in a membrane-anchored form, tethered by Fc or complement receptors2,3,4. Here we show that B-cell interaction with antigens that are immobilized on the surface of a target cell leads to the formation of a synapse and the acquisition, even, of membrane-integral antigens from the target. B-cell antigen receptor accumulates at the synapse, segregated from the CD45 co-receptor which is excluded from the synapse, and there is a corresponding polarization of cytoplasmic effectors in the B cell. B-cell antigen receptor mediates the gathering of antigen into the synapse and its subsequent acquisition, thereby potentiating antigen processing and presentation to T cells with high efficacy. Synapse formation and antigen acquisition will probably enhance the activation of B cells at low antigen concentration, allow context-dependent antigen recognition and enhance the linking of B- and T-cell epitopes.

Date: 2001
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DOI: 10.1038/35078099

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