Molecular consequences of presenilin-1 mutation

C. Russo, G. Schettini, T. C. Saido, C. Hulette, C. Lippa, L. Lannfelt, B. Ghetti, P. Gambetti (), M. Tabaton and J. K. Teller
Additional contact information
C. Russo: Institute of Pathology, Case Western Reserve University
G. Schettini: Institute of Pathology, Case Western Reserve University
T. C. Saido: Institute of Pathology, Case Western Reserve University
C. Hulette: Institute of Pathology, Case Western Reserve University
C. Lippa: Institute of Pathology, Case Western Reserve University
L. Lannfelt: Institute of Pathology, Case Western Reserve University
B. Ghetti: Institute of Pathology, Case Western Reserve University
P. Gambetti: Institute of Pathology, Case Western Reserve University
M. Tabaton: Institute of Pathology, Case Western Reserve University
J. K. Teller: Institute of Pathology, Case Western Reserve University

Nature, 2001, vol. 411, issue 6838, 655-655

Abstract: Abstract Gandy et al. compare our results1 with their 1994 findings2 that the amino-terminally truncated amyloid Aβ11–42 was relatively abundant in two cases of familial Alzheimer's disease involving two distinct mutations in β-APP. However, four important differences should be borne in mind: the authors compare Aβ11–42 with Aβ1–42 and ignore Aβ1–40, although both Aβ1–40 and Aβ1–42 are generated by β-secretase/BACE cleavage at residue Asp 1 (ref. 3); their data are not correlated with features related to disease severity, such as age at onset and duration; they did not examine brains with PS1 mutations (these were not known at that time); and their characterization was based on the use of size-exclusion chromatography and electrospray mass spectrometry to quantify formic-acid-extracted Aβ, whereas we used quantitative analysis of immunoprecipitated water-soluble Aβ on western blots, mass spectrometry to identify Aβ variants, and immunohistochemistry to reveal amino-truncated Aβ peptides in plaques.

Date: 2001
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35079684 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:411:y:2001:i:6838:d:10.1038_35079684

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35079684

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().