p25 protein in neurodegeneration

G. N. Patrick, L. Zukerberg, M. Nikolic, S. de la Monte, P. Dikkes and L.-H. Tsai
Additional contact information
G. N. Patrick: Harvard Medical School and Howard Hughes Medical Institute
L. Zukerberg: Harvard Medical School and Howard Hughes Medical Institute
M. Nikolic: Molecular Neurobiology Group, King's College London
S. de la Monte: Rhode Island Hospital and Brown Medical School
P. Dikkes: Children's Hospital
L.-H. Tsai: Harvard Medical School and Howard Hughes Medical Institute

Nature, 2001, vol. 411, issue 6839, 764-765

Abstract: Abstract Yoo and Lubec show that the amount of p25 is decreased in the brains they studied from patients with Alzheimer's disease or Down's syndrome. Their results persuaded us to conduct a more extensive survey of the p25/p35 ratio in AD brains (to be published elsewhere), as the number of samples was small in both of our studies (eight AD brains in our original study and six in theirs). After analysing a further 25 AD brains and those from 25 age-matched controls, we found that p25 levels are consistently higher in AD brains and that the difference is statistically significant (Student's t-test). This is in agreement with our original observations1, as well as being consistent with earlier reports of increased Cdk5 kinase activity in AD brain2 and of increased amounts of p25 in an animal model of neurodegeneration3.

Date: 2001
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DOI: 10.1038/35081149

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