Subcellular positioning of small molecules

Shuichi Takayama, Emanuele Ostuni, Philip LeDuc, Keiji Naruse, Donald E. Ingber and George M. Whitesides ()
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Shuichi Takayama: Harvard University
Emanuele Ostuni: Harvard University
Philip LeDuc: Children's Hospital and Harvard Medical School
Keiji Naruse: Children's Hospital and Harvard Medical School
Donald E. Ingber: University of Michigan
George M. Whitesides: Harvard University

Nature, 2001, vol. 411, issue 6841, 1016-1016

Abstract: Abstract Localized perturbation of processes that take place inside the living cell depends on molecular and spatial discrimination on a micrometre scale. Here we report the use of multiple laminar streams in a microfluidic channel to deliver membrane-permeable molecules to selected subcellular microdomains. This technique opens up avenues for non-invasively visualizing, probing and manipulating the cellular metabolic and structural machinery.

Date: 2001
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DOI: 10.1038/35082637

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