Natural conjugative plasmids induce bacterial biofilm development

Jean-Marc Ghigo ()
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Jean-Marc Ghigo: Unité des Membranes Bactériennes Institut Pasteur (CNRS URA 2172)

Nature, 2001, vol. 412, issue 6845, 442-445

Abstract: Abstract Horizontal gene transfer is a principal source of evolution leading to change in the ecological character of bacterial species1. Bacterial conjugation2, which promotes the horizontal transfer of genetic material between donor and recipient cells by physical contact, is a phenomenon of fundamental evolutionary consequence3. Although conjugation has been studied primarily in liquid, most natural bacterial populations are found associated with environmental surfaces in complex multispecies communities called biofilms4. Biofilms are ideally suited to the exchange of genetic material of various origins, and it has been shown that bacterial conjugation occurs within biofilms5,6. Here I investigate the direct contribution of conjugative plasmids themselves to the capacity of the bacterial host to form a biofilm. Natural conjugative plasmids expressed factors that induced planktonic bacteria to form or enter biofilm communities, which favour the infectious transfer of the plasmid. This general connection between conjugation and biofilms suggests that medically relevant plasmid-bearing strains are more likely to form a biofilm. This may influence both the chances of biofilm-related infection risks and of conjugational spread of virulence factors.

Date: 2001
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DOI: 10.1038/35086581

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