A new receptor for β-glucans

Gordon D. Brown () and Siamon Gordon
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Gordon D. Brown: Sir William Dunn School of Pathology, University of Oxford
Siamon Gordon: Sir William Dunn School of Pathology, University of Oxford

Nature, 2001, vol. 413, issue 6851, 36-37

Abstract: Abstract The carbohydrate polymers known as β-1,3-d-glucans exert potent effects on the immune system — stimulating antitumour and antimicrobial activity, for example — by binding to receptors on macrophages and other white blood cells and activating them. Although β-glucans are known to bind to receptors, such as complement receptor 3 (ref. 1), there is evidence that another β-glucan receptor is present on macrophages. Here we identify this unknown receptor as dectin-1 (ref. 2), a finding that provides new insights into the innate immune recognition of β-glucans.

Date: 2001
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DOI: 10.1038/35092620

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