Molecular mechanisms of nociception

David Julius () and Allan I. Basbaum
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David Julius: University of California San Francisco
Allan I. Basbaum: University of California San Francisco

Nature, 2001, vol. 413, issue 6852, 203-210

Abstract: Abstract The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where pain messages are initiated — at the level of the primary sensory neuron. Efforts to determine how these neurons detect pain-producing stimuli of a thermal, mechanical or chemical nature have revealed new signalling mechanisms and brought us closer to understanding the molecular events that facilitate transitions from acute to persistent pain.

Date: 2001
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DOI: 10.1038/35093019

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