Stochastic sensors inspired by biology

Hagan Bayley () and Paul S. Cremer
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Hagan Bayley: The Texas A&M University System Health Science Center
Paul S. Cremer: Texas A&M University

Nature, 2001, vol. 413, issue 6852, 226-230

Abstract: Abstract Sensory systems use a variety of membrane-bound receptors, including responsive ion channels, to discriminate between a multitude of stimuli. Here we describe how engineered membrane pores can be used to make rapid and sensitive biosensors with potential applications that range from the detection of biological warfare agents to pharmaceutical screening. Notably, use of the engineered pores in stochastic sensing, a single-molecule detection technology, reveals the identity of an analyte as well as its concentration.

Date: 2001
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DOI: 10.1038/35093038

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