Receptor-specific messenger oscillations

Mark S. Nash, Kenneth W. Young, R. A. John Challiss and Stefan R. Nahorski ()
Additional contact information
Mark S. Nash: Medical Sciences Building, University of Leicester
Kenneth W. Young: Medical Sciences Building, University of Leicester
R. A. John Challiss: Medical Sciences Building, University of Leicester
Stefan R. Nahorski: Medical Sciences Building, University of Leicester

Nature, 2001, vol. 413, issue 6854, 381-382

Abstract: Abstract The cytosolic molecule inositol-1,4,5-trisphosphate (InsP3) acts as a messenger to link receptors at the cell surface with alterations in calcium concentration inside the cell1, but it is not clear how production of InsP3 is related to the often-complex calcium response2. Here we use a fluorescent biosensor to visualize InsP3 synthesis in individual cells in real time and show that this is periodically switched on and off in a receptor-specific manner. Our findings are consistent with intracellular calcium oscillations being generated by either fluctuating or sustained concentrations of InsP3, which may allow diversity of signalling through the same signal-transduction pathway.

Date: 2001
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35096643 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:413:y:2001:i:6854:d:10.1038_35096643

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35096643

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().