Morphogen gradient interpretation

J. B. Gurdon () and P.-Y. Bourillot
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J. B. Gurdon: Wellcome/CRC Institute
P.-Y. Bourillot: Wellcome/CRC Institute

Nature, 2001, vol. 413, issue 6858, 797-803

Abstract: Abstract A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.

Date: 2001
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DOI: 10.1038/35101500

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