Complete genome sequence of Salmonella enterica serovar Typhimurium LT2

Michael McClelland (), Kenneth E. Sanderson, John Spieth, Sandra W. Clifton, Phil Latreille, Laura Courtney, Steffen Porwollik, Johar Ali, Mike Dante, Feiyu Du, Shunfang Hou, Dan Layman, Shawn Leonard, Christine Nguyen, Kelsi Scott, Andrea Holmes, Neenu Grewal, Elizabeth Mulvaney, Ellen Ryan, Hui Sun, Liliana Florea, Webb Miller, Tamberlyn Stoneking, Michael Nhan, Robert Waterston and Richard K. Wilson
Additional contact information
Michael McClelland: Sidney Kimmel Cancer Center
Kenneth E. Sanderson: University of Calgary
John Spieth: Genome Sequencing Center, Washington University School of Medicine
Sandra W. Clifton: Genome Sequencing Center, Washington University School of Medicine
Phil Latreille: Genome Sequencing Center, Washington University School of Medicine
Laura Courtney: Genome Sequencing Center, Washington University School of Medicine
Steffen Porwollik: Sidney Kimmel Cancer Center
Johar Ali: Genome Sequencing Center, Washington University School of Medicine
Mike Dante: Genome Sequencing Center, Washington University School of Medicine
Feiyu Du: Genome Sequencing Center, Washington University School of Medicine
Shunfang Hou: Genome Sequencing Center, Washington University School of Medicine
Dan Layman: Genome Sequencing Center, Washington University School of Medicine
Shawn Leonard: Genome Sequencing Center, Washington University School of Medicine
Christine Nguyen: Genome Sequencing Center, Washington University School of Medicine
Kelsi Scott: Genome Sequencing Center, Washington University School of Medicine
Andrea Holmes: Genome Sequencing Center, Washington University School of Medicine
Neenu Grewal: Genome Sequencing Center, Washington University School of Medicine
Elizabeth Mulvaney: Genome Sequencing Center, Washington University School of Medicine
Ellen Ryan: Genome Sequencing Center, Washington University School of Medicine
Hui Sun: Genome Sequencing Center, Washington University School of Medicine
Liliana Florea: The Pennsylvania State University
Webb Miller: The Pennsylvania State University
Tamberlyn Stoneking: Genome Sequencing Center, Washington University School of Medicine
Michael Nhan: Genome Sequencing Center, Washington University School of Medicine
Robert Waterston: Genome Sequencing Center, Washington University School of Medicine
Richard K. Wilson: Genome Sequencing Center, Washington University School of Medicine

Nature, 2001, vol. 413, issue 6858, 852-856

Abstract: Abstract Salmonella enterica subspecies I, serovar Typhimurium (S. typhimurium), is a leading cause of human gastroenteritis, and is used as a mouse model of human typhoid fever1. The incidence of non-typhoid salmonellosis is increasing worldwide2,3,4, causing millions of infections and many deaths in the human population each year. Here we sequenced the 4,857-kilobase (kb) chromosome and 94-kb virulence plasmid of S. typhimurium strain LT2. The distribution of close homologues of S. typhimurium LT2 genes in eight related enterobacteria was determined using previously completed genomes of three related bacteria, sample sequencing of both S. enterica serovar Paratyphi A (S. paratyphi A) and Klebsiella pneumoniae, and hybridization of three unsequenced genomes to a microarray of S. typhimurium LT2 genes. Lateral transfer of genes is frequent, with 11% of the S. typhimurium LT2 genes missing from S. enterica serovar Typhi (S. typhi), and 29% missing from Escherichia coli K12. The 352 gene homologues of S. typhimurium LT2 confined to subspecies I of S. enterica—containing most mammalian and bird pathogens5—are useful for studies of epidemiology, host specificity and pathogenesis. Most of these homologues were previously unknown, and 50 may be exported to the periplasm or outer membrane, rendering them accessible as therapeutic or vaccine targets.

Date: 2001
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DOI: 10.1038/35101614

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