Key enzyme in leptin-induced anorexia

Kevin D. Niswender, Gregory J. Morton, Walter H. Stearns, Christopher J. Rhodes, Martin G. Myers and Michael W. Schwartz ()
Additional contact information
Kevin D. Niswender: Endocrinology and Nutrition, University of Washington School of Medicine and Harborview Medical Center
Gregory J. Morton: Endocrinology and Nutrition, University of Washington School of Medicine and Harborview Medical Center
Walter H. Stearns: Joslin Diabetes Center, Harvard Medical School
Christopher J. Rhodes: Pacific Northwest Research Institute
Martin G. Myers: Joslin Diabetes Center, Harvard Medical School
Michael W. Schwartz: Endocrinology and Nutrition, University of Washington School of Medicine and Harborview Medical Center

Nature, 2001, vol. 413, issue 6858, 794-795

Abstract: Abstract Leptin is a key hormonal regulator of energy balance that acts upon hypothalamic neurons to reduce food intake, but the intracellular mechanisms involved are incompletely understood. Here we show that systemic administration of leptin in rats activates the enzyme phosphatidylinositol-3-OH kinase (PI(3)K) in the hypothalamus and that intracerebro-ventricular (i.c.v.) infusion of inhibitors of this enzyme prevents leptin-induced anorexia. Our results indicate that PI(3)K is a crucial enzyme in the signal-transduction pathway that links hypothalamic leptin to reduced food intake.

Date: 2001
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35101657 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:413:y:2001:i:6858:d:10.1038_35101657

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35101657

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().