Partial leptin deficiency and human adiposity

I. Sadaf Farooqi, Julia M. Keogh, Sri Kamath, Sarah Jones, William T. Gibson, Rebecca Trussell, Susan A. Jebb, Gregory Y. H. Lip and Stephen O'Rahilly ()
Additional contact information
I. Sadaf Farooqi: Addenbrooke's Hospital
Julia M. Keogh: Addenbrooke's Hospital
Sri Kamath: City Hospital
Sarah Jones: MRC Human Nutrition Research
William T. Gibson: Alberta Children's Hospital
Rebecca Trussell: Alberta Children's Hospital
Susan A. Jebb: MRC Human Nutrition Research
Gregory Y. H. Lip: City Hospital
Stephen O'Rahilly: Addenbrooke's Hospital

Nature, 2001, vol. 414, issue 6859, 34-35

Abstract: Abstract The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice1 and humans2,3 without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).

Date: 2001
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DOI: 10.1038/35102112

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