Stem cells find their niche

Allan Spradling, Daniela Drummond-Barbosa and Toshie Kai
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Allan Spradling: Carnegie Institution of Washington
Daniela Drummond-Barbosa: Carnegie Institution of Washington
Toshie Kai: Carnegie Institution of Washington

Nature, 2001, vol. 414, issue 6859, 98-104

Abstract: Abstract The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.

Date: 2001
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DOI: 10.1038/35102160

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