An anorexic lipid mediator regulated by feeding

F. Rodríguez de Fonseca, M. Navarro, R. Gómez, L. Escuredo, F. Nava, J. Fu, E. Murillo-Rodríguez, A. Giuffrida, J. LoVerme, S. Gaetani, S. Kathuria, C. Gall and D. Piomelli ()
Additional contact information
F. Rodríguez de Fonseca: Complutense University
M. Navarro: Complutense University
R. Gómez: Complutense University
L. Escuredo: Complutense University
F. Nava: Department of Pharmacology
J. Fu: Department of Pharmacology
E. Murillo-Rodríguez: Department of Pharmacology
A. Giuffrida: Department of Pharmacology
J. LoVerme: Department of Pharmacology
S. Gaetani: Department of Pharmacology
S. Kathuria: Department of Pharmacology
C. Gall: University of California
D. Piomelli: Department of Pharmacology

Nature, 2001, vol. 414, issue 6860, 209-212

Abstract: Abstract Oleylethanolamide (OEA) is a natural analogue of the endogenous cannabinoid anandamide. Like anandamide, OEA is produced in cells in a stimulus-dependent manner and is rapidly eliminated by enzymatic hydrolysis, suggesting a function in cellular signalling1. However, OEA does not activate cannabinoid receptors and its biological functions are still unknown2. Here we show that, in rats, food deprivation markedly reduces OEA biosynthesis in the small intestine. Administration of OEA causes a potent and persistent decrease in food intake and gain in body mass. This anorexic effect is behaviourally selective and is associated with the discrete activation of brain regions (the paraventricular hypothalamic nucleus and the nucleus of the solitary tract) involved in the control of satiety. OEA does not affect food intake when injected into the brain ventricles, and its anorexic actions are prevented when peripheral sensory fibres are removed by treatment with capsaicin. These results indicate that OEA is a lipid mediator involved in the peripheral regulation of feeding.

Date: 2001
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DOI: 10.1038/35102582

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