Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins

William M. Gray, Stefan Kepinski, Dean Rouse, Ottoline Leyser and Mark Estelle ()
Additional contact information
William M. Gray: The Institute for Cellular and Molecular Biology, The University of Texas at Austin
Stefan Kepinski: University of York, Box 373
Dean Rouse: University of York, Box 373
Ottoline Leyser: University of York, Box 373
Mark Estelle: The Institute for Cellular and Molecular Biology, The University of Texas at Austin

Nature, 2001, vol. 414, issue 6861, 271-276

Abstract: Abstract The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCFTIR1 and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the function of SCFTIR1 decrease auxin response. Here we show that SCFTIR1 is required for AUX/IAA degradation. We demonstrate that SCFTIR1 interacts with AXR2/IAA7 and AXR3/IAA17, and that domain II of these proteins is necessary and sufficient for this interaction. Further, auxin stimulates binding of SCFTIR1 to the AUX/IAA proteins, and their degradation. Because domain II is conserved in nearly all AUX/IAA proteins in Arabidopsis, we propose that auxin promotes the degradation of this large family of transcriptional regulators, leading to diverse downstream effects.

Date: 2001
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/35104500 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:414:y:2001:i:6861:d:10.1038_35104500

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35104500

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().