HLA-DQ7 antigen and resistance to variant CJD

Graham S. Jackson, Jonathan A. Beck, Cristina Navarrete, Juliette Brown, P. Margaret Sutton, Marcela Contreras and John Collinge ()
Additional contact information
Graham S. Jackson: MRC Prion Unit, Institute of Neurology, University College London
Jonathan A. Beck: MRC Prion Unit, Institute of Neurology, University College London
Cristina Navarrete: National Blood Service, Histocompatibility and Immunogenetics
Juliette Brown: National Blood Service, Histocompatibility and Immunogenetics
P. Margaret Sutton: Oxford Transplant Centre, Oxford Radcliffe Hospitals
Marcela Contreras: National Blood Service, Histocompatibility and Immunogenetics
John Collinge: MRC Prion Unit, Institute of Neurology, University College London

Nature, 2001, vol. 414, issue 6861, 269-270

Abstract: Abstract Variant Creutzfeldt–Jakob disease (vCJD) in humans is caused by a bovine spongiform encephalopathy (BSE)-like prion strain, and so far about 100 of the many people exposed to BSE prions have developed the condition. Here we show that there is a significantly reduced frequency of the human leukocyte antigen (HLA) class-II type DQ7 in patients with vCJD, but not in those with classical CJD. This apparently protective genetic factor should aid differential diagnosis and may have important implications for understanding host susceptibility to infection by BSE prions, and the distinctive pathogenesis of vCJD, as well as in the identification of targets for prevention and therapy of vCJD.

Date: 2001
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/35104694 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:414:y:2001:i:6861:d:10.1038_35104694

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/35104694

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().