Extending the lifespan of long-lived mice

Andrzej Bartke (), J. Chris Wright, Julie A. Mattison, Donald K. Ingram, Richard A. Miller and George S. Roth
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Andrzej Bartke: School of Medicine, Southern Illinois University
J. Chris Wright: School of Medicine, Southern Illinois University
Julie A. Mattison: National Institute on Aging, NIH Animal Center
Donald K. Ingram: National Institute on Aging, NIH Animal Center
Richard A. Miller: University of Michigan
George S. Roth: Gerontology Research Center

Nature, 2001, vol. 414, issue 6862, 412-412

Abstract: Abstract Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings1,2,3 because they carry a 'longevity' gene, Prop1df, and in some phenotypic respects they resemble normal mice whose lifespan has been extended by restricted food intake2,4,5. Here we investigate whether these factors influence lifespan by similar or independent mechanisms, by deliberately reducing the number of calories consumed by Ames dwarf mice. We show that calorie restriction confers a further lifespan increase in the dwarfs, indicating that the two factors may act through different pathways.

Date: 2001
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DOI: 10.1038/35106646

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