Conserved signals and machinery for RNA transport in Drosophila oogenesis and embryogenesis

Simon L. Bullock and David Ish-Horowicz ()
Additional contact information
Simon L. Bullock: Developmental Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123
David Ish-Horowicz: Developmental Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123

Nature, 2001, vol. 414, issue 6864, 611-616

Abstract: Abstract Localization of cytoplasmic messenger RNA transcripts is widely used to target proteins within cells. For many transcripts, localization depends on cis-acting elements within the transcripts and on microtubule-based motors; however, little is known about other components of the transport machinery or how these components recognize specific RNA cargoes. Here, we show that in Drosophila the same machinery and RNA signals drive specific accumulation of maternal RNAs in the early oocyte and apical transcript localization in blastoderm embryos. We demonstrate in vivo that Egalitarian (Egl) and Bicaudal D (BicD), maternal proteins required for oocyte determination, are selectively recruited by, and co-transported with, localizing transcripts in blastoderm embryos, and that interfering with the activities of Egl and BicD blocks apical localization. We propose that Egl and BicD are core components of a selective dynein motor complex that drives transcript localization in a variety of tissues.

Date: 2001
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/414611a Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:414:y:2001:i:6864:d:10.1038_414611a

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/414611a

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().