β-Cell death during progression to diabetes

Diane Mathis, Luis Vence and Christophe Benoist ()
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Diane Mathis: Section on Immunology and Immunogenetics, Joslin Diabetes Centre
Luis Vence: Brigham and Women's Hospital
Christophe Benoist: Harvard Medical School

Nature, 2001, vol. 414, issue 6865, 792-798

Abstract: Abstract The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of β-cells may be crucial at several points during disease progression, initiating leukocyte invasion of the islets and terminating the production of insulin in islet cells. β-Cell apoptosis may also be involved in the occasional evolution of type 2 into type 1 diabetes.

Date: 2001
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DOI: 10.1038/414792a

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