Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel () and C. Ronald Kahn ()
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Alan R. Saltiel: Life Sciences Institute, University of Michigan School of Medicine
C. Ronald Kahn: Joslin Diabetes Centre, Harvard Medical School

Nature, 2001, vol. 414, issue 6865, 799-806

Abstract: Abstract The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin. This state is also linked to other common health problems, such as obesity, polycystic ovarian disease, hyperlipidaemia, hypertension and atherosclerosis. The pathophysiology of insulin resistance involves a complex network of signalling pathways, activated by the insulin receptor, which regulates intermediary metabolism and its organization in cells. But recent studies have shown that numerous other hormones and signalling events attenuate insulin action, and are important in type 2 diabetes.

Date: 2001
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DOI: 10.1038/414799a

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