Biochemistry and molecular cell biology of diabetic complications

Michael Brownlee ()
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Michael Brownlee: Albert Einstein College of Medicine

Nature, 2001, vol. 414, issue 6865, 813-820

Abstract: Abstract Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.

Date: 2001
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DOI: 10.1038/414813a

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