The genome sequence of Schizosaccharomyces pombe

Wood, V.; Gwilliam, R.; Rajandream, M.-A.; Lyne, M.; Lyne, R.; Stewart, A.; Sgouros, J.; Peat, N.; Hayles, J.; Baker, S.; Basham, D.; Bowman, S.; Brooks, K.; Brown, D.; Brown, S.; Chillingworth, T.; Churcher, C.; Collins, M.; Connor, R.; Cronin, A.; Davis, P.; Feltwell, T.; Fraser, A.; Gentles, S.; Goble, A.; Hamlin, N.; Harris, D.; Hidalgo, J.; Hodgson, G.; Holroyd, S.; Hornsby, T.; Howarth, S.; Huckle, E. J.; Hunt, S.; Jagels, K.; James, K.; Jones, L.; Jones, M.; Leather, S.; McDonald, S.; McLean, J.; Mooney, P.; Moule, S.; Mungall, K.; Murphy, L.; Niblett, D.; Odell, C.; Oliver, K.; O'Neil, S.; Pearson, D.; Quail, M. A.; Rabbinowitsch, E.; Rutherford, K.; Rutter, S.; Saunders, D.; Seeger, K.; Sharp, S.; Skelton, J.; Simmonds, M.; Squares, R.; Squares, S.; Stevens, K.; Taylor, K.; Taylor, R. G.; Tivey, A.; Walsh, S.; Warren, T.; Whitehead, S.; Woodward, J.; Volckaert, G.; Aert, R.; Robben, J.; Grymonprez, B.; Weltjens, I.; Vanstreels, E.; Rieger, M.; Schäfer, M.; Müller-Auer, S.; Gabel, C.; Fuchs, M.; Fritzc, C.; Holzer, E.; Moestl, D.; Hilbert, H.; Borzym, K.; Langer, I.; Beck, A.; Lehrach, H.; Reinhardt, R.; Pohl, T. M.; Eger, P.; Zimmermann, W.; Wedler, H.; Wambutt, R.; Purnelle, B.; Goffeau, A.; Cadieu, E.; Dréano, S.; Gloux, S.; Lelaure, V.; Mottier, S.; Galibert, F.; Aves, S. J.; Xiang, Z.; Hunt, C.; Moore, K.; Hurst, S. M.; Lucas, Maria Raquel; Rochet, M.; Gaillardin, C.; Tallada, V. A.; Garzon, A.; Thode, G.; Daga, R. R.; Cruzado, L.; Jimenez, J.; Sánchez, M.; Rey, F. del; Benito, J.; Domínguez, A.; Revuelta, J. L.; Moreno, S.; Armstrong, J.; Forsburg, S. L.; Cerrutti, L.; Lowe, T.; McCombie, W. R.; Paulsen, I.; Potashkin, J.; Shpakovski, G. V.; Ussery, D.; Barrell, B. G.; Nurse, P.

The genome sequence of Schizosaccharomyces pombe

V. Wood, R. Gwilliam, M.-A. Rajandream (), M. Lyne, R. Lyne, A. Stewart, J. Sgouros, N. Peat, J. Hayles, S. Baker, D. Basham, S. Bowman, K. Brooks, D. Brown, S. Brown, T. Chillingworth, C. Churcher, M. Collins, R. Connor, A. Cronin, P. Davis, T. Feltwell, A. Fraser, S. Gentles, A. Goble, N. Hamlin, D. Harris, J. Hidalgo, G. Hodgson, S. Holroyd, T. Hornsby, S. Howarth, E. J. Huckle, S. Hunt, K. Jagels, K. James, L. Jones, M. Jones, S. Leather, S. McDonald, J. McLean, P. Mooney, S. Moule, K. Mungall, L. Murphy, D. Niblett, C. Odell, K. Oliver, S. O'Neil, D. Pearson, M. A. Quail, E. Rabbinowitsch, K. Rutherford, S. Rutter, D. Saunders, K. Seeger, S. Sharp, J. Skelton, M. Simmonds, R. Squares, S. Squares, K. Stevens, K. Taylor, R. G. Taylor, A. Tivey, S. Walsh, T. Warren, S. Whitehead, J. Woodward, G. Volckaert, R. Aert, J. Robben, B. Grymonprez, I. Weltjens, E. Vanstreels, M. Rieger, M. Schäfer, S. Müller-Auer, C. Gabel, M. Fuchs, C. Fritzc, E. Holzer, D. Moestl, H. Hilbert, K. Borzym, I. Langer, A. Beck, H. Lehrach, R. Reinhardt, T. M. Pohl, P. Eger, W. Zimmermann, H. Wedler, R. Wambutt, B. Purnelle, A. Goffeau, E. Cadieu, S. Dréano, S. Gloux, V. Lelaure, S. Mottier, F. Galibert, S. J. Aves, Z. Xiang, C. Hunt, K. Moore, S. M. Hurst, Maria Raquel Lucas (), M. Rochet, C. Gaillardin, V. A. Tallada, A. Garzon, G. Thode, R. R. Daga, L. Cruzado, J. Jimenez, M. Sánchez, F. del Rey, J. Benito, A. Domínguez, J. L. Revuelta, S. Moreno, J. Armstrong, S. L. Forsburg, L. Cerrutti, T. Lowe, W. R. McCombie, I. Paulsen, J. Potashkin, G. V. Shpakovski, D. Ussery, B. G. Barrell and P. Nurse
Additional contact information
V. Wood: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
R. Gwilliam: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
M.-A. Rajandream: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
M. Lyne: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
R. Lyne: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
A. Stewart: Cancer Research UK London Research Institute, Computational Genome Analysis Laboratory
J. Sgouros: Cancer Research UK London Research Institute, Computational Genome Analysis Laboratory
N. Peat: Cancer Research UK London Research Institute, Cell Cycle Laboratory
J. Hayles: Cancer Research UK London Research Institute, Cell Cycle Laboratory
S. Baker: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
D. Basham: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Bowman: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Brooks: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
D. Brown: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Brown: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
T. Chillingworth: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
C. Churcher: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
M. Collins: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
R. Connor: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
A. Cronin: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
P. Davis: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
T. Feltwell: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
A. Fraser: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Gentles: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
A. Goble: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
N. Hamlin: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
D. Harris: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
J. Hidalgo: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
G. Hodgson: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Holroyd: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
T. Hornsby: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Howarth: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
E. J. Huckle: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Hunt: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Jagels: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. James: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
L. Jones: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
M. Jones: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Leather: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. McDonald: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
J. McLean: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
P. Mooney: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Moule: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Mungall: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
L. Murphy: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
D. Niblett: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
C. Odell: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Oliver: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. O'Neil: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
D. Pearson: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
M. A. Quail: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
E. Rabbinowitsch: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Rutherford: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Rutter: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
D. Saunders: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Seeger: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Sharp: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
J. Skelton: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
M. Simmonds: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
R. Squares: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Squares: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Stevens: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
K. Taylor: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
R. G. Taylor: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
A. Tivey: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Walsh: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
T. Warren: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
S. Whitehead: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
J. Woodward: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
G. Volckaert: Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F
R. Aert: Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F
J. Robben: Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F
B. Grymonprez: Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F
I. Weltjens: Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F
E. Vanstreels: Katholieke Universiteit Leuven, Faculty of Agricultural and Applied Biological Sciences, Laboratory of Gene Technology, Kardinaal Mercierlaan 92 Blok F
M. Rieger: Genotype GmbH, Molecular Biology and Biotech Research
M. Schäfer: Genotype GmbH, Molecular Biology and Biotech Research
S. Müller-Auer: Genotype GmbH, Molecular Biology and Biotech Research
C. Gabel: Genotype GmbH, Molecular Biology and Biotech Research
M. Fuchs: Genotype GmbH, Molecular Biology and Biotech Research
C. Fritzc: QIAGEN GmbH
E. Holzer: QIAGEN GmbH
D. Moestl: QIAGEN GmbH
H. Hilbert: QIAGEN GmbH
K. Borzym: Max-Planck-Institut für molekulare Genetik
I. Langer: Max-Planck-Institut für molekulare Genetik
A. Beck: Max-Planck-Institut für molekulare Genetik
H. Lehrach: Max-Planck-Institut für molekulare Genetik
R. Reinhardt: Max-Planck-Institut für molekulare Genetik
T. M. Pohl: GATC Biotech AG
P. Eger: GATC Biotech AG
W. Zimmermann: AGOWA GmbH
H. Wedler: AGOWA GmbH
R. Wambutt: AGOWA GmbH
B. Purnelle: Université de Louvain, Unite de Biochimie Physiologique
A. Goffeau: Université de Louvain, Unite de Biochimie Physiologique
E. Cadieu: UMR 6061 CNRS Genetique et developpement, Faculté de Médecine
S. Dréano: UMR 6061 CNRS Genetique et developpement, Faculté de Médecine
S. Gloux: UMR 6061 CNRS Genetique et developpement, Faculté de Médecine
V. Lelaure: UMR 6061 CNRS Genetique et developpement, Faculté de Médecine
S. Mottier: UMR 6061 CNRS Genetique et developpement, Faculté de Médecine
F. Galibert: UMR 6061 CNRS Genetique et developpement, Faculté de Médecine
S. J. Aves: University of Exeter, School of Biological Sciences, Washington Singer Laboratories
Z. Xiang: University of Exeter, School of Biological Sciences, Washington Singer Laboratories
C. Hunt: University of Exeter, School of Biological Sciences, Washington Singer Laboratories
K. Moore: University of Exeter, School of Biological Sciences, Washington Singer Laboratories
S. M. Hurst: University of Exeter, School of Biological Sciences, Washington Singer Laboratories
M. Rochet: Génétique Moléculaire et Cellulaire, CNRS URA1925 INRA UMR216, Institut National Agronomique Paris-Grignon
C. Gaillardin: Génétique Moléculaire et Cellulaire, CNRS URA1925 INRA UMR216, Institut National Agronomique Paris-Grignon
V. A. Tallada: Facultad de Ciencias, Universidad de Malaga
A. Garzon: Facultad de Ciencias, Universidad de Malaga
G. Thode: Facultad de Ciencias, Universidad de Malaga
R. R. Daga: Facultad de Ciencias, Universidad de Malaga
L. Cruzado: Facultad de Ciencias, Universidad de Malaga
J. Jimenez: Facultad de Ciencias, Universidad de Malaga
M. Sánchez: Instituto de Microbiología y Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno
F. del Rey: Instituto de Microbiología y Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno
J. Benito: Instituto de Microbiología y Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno
A. Domínguez: Instituto de Microbiología y Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno
J. L. Revuelta: Instituto de Microbiología y Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno
S. Moreno: Instituto de Microbiología y Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno
J. Armstrong: University of Sussex, Falmer
S. L. Forsburg: Molecular & Cell Biology Laboratory, Salk Institute for Biological Studies
L. Cerrutti: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
T. Lowe: Stanford University, Stanford University School of Medicine, CCSR Room 2255b
W. R. McCombie: Cold Spring Harbor Laboratory, PO Box 100
I. Paulsen: TIGR
J. Potashkin: The Chicago Medical School
G. V. Shpakovski: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
D. Ussery: Center for Biological Sequence Analysis, BioCentrum-DTU, The Technical University of Denmark, Building 208
B. G. Barrell: The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton
P. Nurse: Cancer Research UK London Research Institute, Cell Cycle Laboratory

Nature, 2002, vol. 415, issue 6874, 871-880

Abstract: Abstract We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres are between 35 and 110 kilobases (kb) and contain related repeats including a highly conserved 1.8-kb element. Regions upstream of genes are longer than in budding yeast (Saccharomyces cerevisiae), possibly reflecting more-extended control regions. Some 43% of the genes contain introns, of which there are 4,730. Fifty genes have significant similarity with human disease genes; half of these are cancer related. We identify highly conserved genes important for eukaryotic cell organization including those required for the cytoskeleton, compartmentation, cell-cycle control, proteolysis, protein phosphorylation and RNA splicing. These genes may have originated with the appearance of eukaryotic life. Few similarly conserved genes that are important for multicellular organization were identified, suggesting that the transition from prokaryotes to eukaryotes required more new genes than did the transition from unicellular to multicellular organization.

Date: 2002
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DOI: 10.1038/nature724

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