Functional neurogenesis in the adult hippocampus

Henriette van Praag (), Alejandro F. Schinder, Brian Christie, Nicolas Toni, Theo D. Palmer and Fred H. Gage
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Henriette van Praag: Laboratory of Genetics, The Salk Institute for Biological Studies
Alejandro F. Schinder: Laboratory of Genetics, The Salk Institute for Biological Studies
Nicolas Toni: Laboratory of Genetics, The Salk Institute for Biological Studies
Theo D. Palmer: Laboratory of Genetics, The Salk Institute for Biological Studies
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies

Nature, 2002, vol. 415, issue 6875, 1030-1034

Abstract: Abstract There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory1,2,3,4,5. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.

Date: 2002
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DOI: 10.1038/4151030a

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