Characterization of a common precursor population for dendritic cells

Gloria Martínez del Hoyo, Pilar Martín, Héctor Hernández Vargas, Sara Ruiz, Cristina Fernández Arias and Carlos Ardavín
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Gloria Martínez del Hoyo: Faculty of Biology, Complutense University
Pilar Martín: Faculty of Biology, Complutense University
Héctor Hernández Vargas: Faculty of Biology, Complutense University
Sara Ruiz: Faculty of Biology, Complutense University
Cristina Fernández Arias: Faculty of Biology, Complutense University
Carlos Ardavín: Faculty of Biology, Complutense University

Nature, 2002, vol. 415, issue 6875, 1043-1047

Abstract: Abstract Dendritic cells (DCs) are essential for the establishment of immune responses against pathogens and tumour cells, and thus have great potential as tools for vaccination and cancer immunotherapy trials. Experimental evidence has led to a dual DC differentiation model, which involves the existence of both myeloid- and lymphoid-derived DCs1. But this concept has been challenged by recent reports demonstrating that both CD8- and CD8+ DCs, considered in mice as archetypes of myeloid and lymphoid DCs respectively, can be generated from either lymphoid2,3,4 or myeloid progenitors3,4. The issue of DC physiological derivation therefore remains an open question. Here we report the characterization of a DC-committed precursor population, which has the capacity to generate all the DC subpopulations present in mouse lymphoid organs—including CD8- and CD8+ DCs, as well as the B220+ DC subset—but which is devoid of myeloid or lymphoid differentiation potential. These data support an alternative model of DC development, in which there is an independent, common DC differentiation pathway.

Date: 2002
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DOI: 10.1038/4151043a

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